Understand clinical trials
ClinicalTrials.gov explains how to read study records and contact study teams about participation.
Learn about participation ↗Explore primary ovarian insufficiency research, save studies that matter to you, and prepare a conversation with your care team.
Searching primary and premature ovarian insufficiency, including the older registry term “premature ovarian failure.” Start with recruiting studies of all types, then narrow by your priorities.
POI involves loss of ovarian activity before age 40. Research spans hormones, fertility, genetics, bone health, and quality of life. Check each study’s age and diagnosis requirements with the study team.
PRP and stem-cell studies are experimental research, not established ways to restore ovarian function or fertility. A registry listing does not establish safety, effectiveness, or regulatory approval.
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Live ClinicalTrials.gov records, with filters tailored to your search.
Recruiting sites only excludes sites with missing status. Confirm openings directly with the site.
Separate excluded terms with commas. Mentions in inclusion or exclusion criteria both count, so broad exclusions may hide relevant studies. Intervention categories use listed intervention names, including comparison arms, and may be incomplete. Related or mixed-condition studies may appear; confirm eligibility with the study team.
New means first posted on ClinicalTrials.gov. Updated means an older record was updated; newly posted records appear only under New. Uses today and the previous 29 calendar days (UTC). An update does not necessarily mean new slots or changed eligibility. Counts reflect the other filters and trial group. Results are sorted by the relevant posting date, newest first.
Reliable places to learn, connect, and ask for practical help.
ClinicalTrials.gov explains how to read study records and contact study teams about participation.
Learn about participation ↗Read evidence-based guidance covering diagnosis, hormone therapy, fertility, bone health, and ongoing care.
ASRM / ESHRE POI guideline ↗NIH / NICHD POI research ↗
Includes NIH intramural research on POI.
Bring your diagnosis, treatment history, and questions to your care-team visit. Connect through these websites: